The Oxyclozanide Market had a substantial global size in 2020 and is expected to continue growing at a rapid pace, with a consistently increasing revenue compound annual growth rate (CAGR) from 2021 to 2028. The market growth is primarily driven by factors such as high demand from the veterinary sector for regular usage, capacity expansion by key companies, and extensive research and development activities conducted by major pharmaceutical and academic institutions worldwide.
Oxyclozanide is a salicylanilide anthelmintic agent used for the treatment and prevention of fascioliasis in ruminants, particularly domestic animals like cattle, sheep, and goats. It is available in different forms, including oral drench, combinations with levamisole hydrochloride or oxfendazole, and powder for feed mixing. Its main mechanism of action against flukes involves uncoupling oxidative phosphorylation. The recommended dosage varies, with 15 mg per kilogram of body weight for goats and sheep, and 10 to 15 mg per kilogram of body weight for cattle. However, the application of oxyclozanide is not suitable for goat milk and tissues, as well as sheep milk. High doses of oxyclozanide can lead to severe respiratory disorders, salivation, tachycardia, and fever.
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Key Factors Driving the Growth of the Global Oxyclozanide Market: The global oxyclozanide market is expected to witness steady growth due to increasing usage. Consequently, the production of oxyclozanide is projected to escalate in the coming years, with an estimated output of 1230.0 MT in 2023. The prices of oxyclozanide are anticipated to continue their moderate declining trend in the future. Research activities have revealed that oxyclozanide, a veterinary drug, targets the cell membrane rather than intracellular pathways, reducing the likelihood of drug resistance development. It has also shown effectiveness in treating drug-resistant staphylococcal infections.
Furthermore, niclosamide, included in the World Health Organization's list of essential medicines, has demonstrated the ability to preserve infected nematode worms and inhibit the growth of Methicillin-resistant Staphylococcus Aureus (MRSA) cultures. Oxyclozanide, when used at lower concentrations, has proven to be highly effective compared to vancomycin, the current last-resort clinical treatment. In laboratory tests, oxyclozanide has also exhibited efficacy against Enterococcus faecium, a gram-positive pathogen.
Factors Restraining the Growth of the Global Oxyclozanide Market: The growth of the global oxyclozanide market is significantly hindered by various unfavorable factors, primarily toxicity. Ruminants exposed to oxyclozanide toxicity may experience symptoms such as depression, loss of appetite, and diarrhea, with the liver being the most affected organ. Toxicity symptoms observed in rat studies include pallor, increased respiration, lethargy, fecal and urine staining of the perineum, and muzzle staining. Additionally, oxyclozanide has some side effects, including mild and transient adverse drug reactions (ADRs) at therapeutic doses. Unfortunately, there is currently no specific antidote for oxyclozanide toxicity, and treatment is limited to supportive and symptomatic measures.
Opportunities for Players in the Global Oxyclozanide Market: The oxyclozanide market accommodates numerous companies of varying sizes worldwide, actively striving to gain a competitive advantage. These companies are investing significant resources in research and development to develop cutting-edge drugs. Some are also adopting organic and inorganic strategies, such as joint ventures, mergers and acquisitions, collaborations and partnerships, and new product launches, to effectively compete with their rivals.
Global Oxyclozanide Market Revenue by Type Segment: The global oxyclozanide market is segmented by type into content 98% and content 99%. Among these segments, content 98% is expected to remain the dominant segment in the coming years. The pharmacodynamic action of oxyclozanide necessitates lower dosage administration to animals to avoid adverse effects on intestinal function and the central nervous system.
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Leading Application Segment in the Global Oxyclozanide Market: In terms of application, the feed additives segment is projected to generate the highest revenue share in the oxyclozanide market in the near future. Oxyclozanide is commonly used as a feed additive in various disciplines, including cattle feeds, sheep feeds, pig feeds, and other animal feeds. The high demand for swine feed is another factor that will contribute to the growth of the oxyclozanide market.
North America Holds the Largest Revenue Share in the Global Oxyclozanide Market: North America is expected to dominate the oxyclozanide market in terms of revenue share during the forecast period. The region's growth is driven by the increasing prevalence of diseases among animals, particularly cattle, which will boost the demand for oxyclozanide.
Africa and Asia Pacific Lead in Terms of Revenue CAGR: Africa and Asia Pacific are anticipated to exhibit the highest revenue compound annual growth rate (CAGR) during the forecast period. Africa held the largest share in the oxyclozanide market in 2020, while India is the second-largest market in the Asia Pacific region. India currently houses the majority of the world's oxyclozanide manufacturers. Additionally, the expansion of the agriculture industry and the growing number of cattle in developing countries will drive the growth of the oxyclozanide market in both Asia Pacific and Africa.
Major Companies Profiled in the Report: The report includes profiles of major companies operating in the oxyclozanide market, such as Siflon Drugs, Yabang, Gharda, ASCENT PHARMA, Aarambh Life Science, ProVentus, Excel Industries, Konar Organics, Neha Pharma, H. Organics, and Neeta Interchem. These companies are implementing various strategies and objectives to stay competitive in the market. For instance, in August 2021, Lasa Supergenerics Limited launched oxyclozanide as part of its product portfolio. The company, based in India, manufactures veterinary and human active pharmaceutical ingredients (APIs) and now has a total capacity of 250 MT.
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Detailed Segmentation in Our Report: The global oxyclozanide market is segmented based on type, application, and region. The type segment includes content 98% and content 99%. The application segment comprises injectables, oral liquids, and feed additives. Geographically, the market is divided into North America (U.S., Canada, Mexico), Europe (Germany, U.K., France, Italy, Spain, Benelux, Rest of Europe), Asia Pacific (China, India, Japan, South Korea, Rest of Asia Pacific), Latin America (Brazil, Rest of Latin America), and Middle East & Africa (Saudi Arabia, UAE, South Africa, Rest of Middle East & Africa).
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