Bacterial endoglycosidases, particularly those from the glycoside hydrolase families GH18 and GH20, possess unique capabilities to cleave the glycosidic bonds within the chitobiose core of N-linked glycans. Enzymes like EndoE (from Enterococcus faecalis), EndoS (from Streptococcus pyogenes), and EndoF variants are widely utilized to deglycosylate IgG antibodies or remodel glycans on...
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