PROTAC Design: A Novel Approach in Targeted Protein Degradation Introduction
The Mechanisms of protein regulation and degradation are crucial for maintaining cellular homeostasis and preventing diseases such as cancer. One of the most innovative approaches in pharmacology is the development of Proteolysis Targeting Chimeras (PROTACs), small molecules designed to promote the ubiquitin-proteasome pathway for targeted protein degradation. PROTACs have emerged...