Introduction to Integrative Multi-omics Analyses
One of the first stages in microbial systems biology has been allocated to genomics by the convenience at which genomes are presently sequenced. Regardless of the method utilized, genome sequencing is usually accompanied by arrangement and encoding and returns an almost full view of a given microorganism's genetic reservoir. On the other side,...
Introduction to Integrative Multi-omics Analyses
One of the first stages in microbial systems biology has been allocated to genomics by the convenience at which genomes are presently sequenced. Regardless of the method utilized, genome sequencing is usually accompanied by arrangement and encoding and returns an almost full view of a given microorganism's genetic reservoir. On the other side,...
The term microbiome comes from the Greek word micro, which means small, and bio, meaning life. It is defined as "a characteristic microbial community occupying a reasonably well-defined habitat which has distinct physicochemical properties". Many researchers in the past defined microbiome based on different contexts, such as ecological and genetic aspects. However, scientists noted some gaps in...
RNA sequencing (RNA-Seq) has revolutionized transcriptome analysis, providing valuable insights into gene expression, transcript structure, and variation. However, the detection of rare or low-abundance expressed genes remains a challenge due to the vast size and complexity of the transcriptome. To overcome these limitations, targeted RNA sequencing has emerged as a powerful...
When a ribosome is affixed to the polypeptide (protein) it is making, the ribosome-nascent chain complex (RNC) is the compilation of molecules that make up the ribosome. One of several methods can be used to halt the synthesis of the nascent polypeptide. RNCs are made and purified in labs to study the dynamics, biochemistry, folding, and interactions that the ribosome and proteins undergo...
What is Single-Cell ATAC Sequencing (scATAC-seq)?
Single-cell ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) is an innovative technique that enables the investigation of chromatin accessibility at the single-cell level. The accessibility of chromatin—whether it is in an open or closed configuration—critically impacts gene expression and cell fate....
EM-seq (Enzymatic Methyl-sequencing), a cutting-edge technique for identifying DNA methylation profiles, is showing great potential in various fields, including epigenetic research, disease diagnosis, and the early detection of cancer. Compared to the traditional whole-genome bisulfite sequencing (WGBS), EM-seq offers several advantages. It allows for the creation of DNA sequencing...
Principal Component Analysis (PCA) is a technology for simplified analysis of data sets. PCA uses variance decomposition to reduce the dimensionality of multi-dimensional data, remove noise and redundancy, and reveal the most important elements and structures hidden behind complex data. In the field of life sciences, in proteomics and metabolomics research applications, it is usually necessary...
Evolutionary analysis can reveal the genetic sequence relationship of classification in the evolution process from the perspective of molecular evolution. In the process of biological information analysis, phylogenetic trees are often used to present the analysis results. The phylogenetic tree can reveal the biological evolution process and mechanism of related species or genes. The...
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